Lower Serum Leptin Concentrations in Female Subjects with Type 2 Diabetes Mellitus

女性第2型糖尿病病人血清瘦素濃度較低

陳清助(Ching-Chu Chen) ； 李采娟(Tsai-Chung Li) ； 張淳堆(Chwen-Tzuei Chang) ； 簡誌銘(Chih-Ming Chien) ； 陳榮興(Rong-Hshing Chen) ； 王子源(Tzu-Yuan Wang)

《Mid-Taiwan Journal of Medicine》 8卷1期 (2003/03) Pp. 8-12

https://doi.org/10.6558/MTJM.2003.8(1).2

摘要

Objectives: Leptin is an adipocyte-secreting hormone which regulates appetite and body weight. Its concentration differs among different diseases. The purpose of this study was to compare leptin concentrations between subjects with type 2 diabetes mellitus (DM) and healthy subjects.
Methods: We recruited 172 subjects with type 2 DM (75males and 97 females) and 158 healthy subjects (79 males and 79 females) for this study. Fasting plasma glucose, serum insulin and leptin concentrations, and body mass index (BMI) were measured.
Results: The serum leptin concentration of subjects with type 2 DM was lower than in the control group (6.1 ± 5.2 vs 7.5 ± 5.8 ng/mL, ρ=0.020; log leptin 1.1 ± 0.8 vs 1.7 ± 0.9, ρ= 0.047). In male subjects, the serum leptin concentration did not differ significantly between the two groups (3.9 ± 3.6 vs 3.8 ± 3.1 ng/mL, ρ= 0.803; log leptin 1.1 ± 0.7 vs 1.1 ± 0.7, ρ= 0.906). However, in female subjects, the serum leptin concentration was significantly lower than in the control group (7.8 ± 5.6 vs 11.3 ± 5.4 ng/mL, ρ＜ 0.001; log leptin 1.8 ± 0.7 vs 2.3 ± 05, ρ＜ 0.001). According to multiple linear regression analysis with log leptin as a dependent variable, the mean log leptin concentration of female subjects with type 2 DM was 0.455 ng/mL (ρ＜ 0.001) lower than thecontrol group after adjusting for age and BMI.
Conclusions: The leptin concentration of female subjects with type 2 DM is lower than in healthy subjects.

關鍵字

女性 ； 瘦素 ； 較低 ； 男性 ； 第2型糖尿病

並列摘要

Objectives: Leptin is an adipocyte-secreting hormone which regulates appetite and body weight. Its concentration differs among different diseases. The purpose of this study was to compare leptin concentrations between subjects with type 2 diabetes mellitus (DM) and healthy subjects.
Methods: We recruited 172 subjects with type 2 DM (75males and 97 females) and 158 healthy subjects (79 males and 79 females) for this study. Fasting plasma glucose, serum insulin and leptin concentrations, and body mass index (BMI) were measured.
Results: The serum leptin concentration of subjects with type 2 DM was lower than in the control group (6.1 ± 5.2 vs 7.5 ± 5.8 ng/mL, ρ=0.020; log leptin 1.1 ± 0.8 vs 1.7 ± 0.9, ρ= 0.047). In male subjects, the serum leptin concentration did not differ significantly between the two groups (3.9 ± 3.6 vs 3.8 ± 3.1 ng/mL, ρ= 0.803; log leptin 1.1 ± 0.7 vs 1.1 ± 0.7, ρ= 0.906). However, in female subjects, the serum leptin concentration was significantly lower than in the control group (7.8 ± 5.6 vs 11.3 ± 5.4 ng/mL, ρ＜ 0.001; log leptin 1.8 ± 0.7 vs 2.3 ± 05, ρ＜ 0.001). According to multiple linear regression analysis with log leptin as a dependent variable, the mean log leptin concentration of female subjects with type 2 DM was 0.455 ng/mL (ρ＜ 0.001) lower than thecontrol group after adjusting for age and BMI.
Conclusions: The leptin concentration of female subjects with type 2 DM is lower than in healthy subjects.

並列關鍵字

female ； leptin ； lower ； male ； type 2 DM