Sulfotransferase lAl is a Risk Factor for Breast Cancer in Young Women

Sulfotransferase 1A1是年輕女性乳癌的危險因子

陳守棟(Shou-Tung Chen) ； 陳瑞彰(Jui-Chang Chen) ； 侯明鋒(Ming-Fong Hou) ； 葉坤土(Kun-Tu Yeh) ； 李黛苹(Tai-Ping Lee) ； 陳志玫(Chih-Mei Chen) ； 施木青(Mu-Chin Shih) ； 張建國(Jan-Gowth Chang)

《Mid-Taiwan Journal of Medicine》 8卷2期 (2003/06) Pp. 59-65

https://doi.org/10.6558/MTJM.2003.8(2).1

摘要

目的 SULT1A1是細胞中主要的轉?酵素，它活化或代謝很多的化學物及致癌物，SULT1A1多形性與癌症的相關性尚未清楚。
方法 我們利用PCR-RFLP的方法分析SULT1A1的多形性變異，並分析此變異與幾種癌症的相關性。
結果 在分析76個肝癌，180個乳癌，61個肺癌，52個口腔癌及74個胃癌病人後，SULT1A1*1在上述病人的發生率分別為96.1%，94.2%，95.1%，96.1%，及97.3%；而SULT1A1*2的發生率則分別為.9%，5.8%，4.9%，3.9%，及2.7%；並沒有發現.9%，5.8%，4.9%，3.9%，and 2.7%*3的存在。
結論比較正常人SULT1A1的發生率(SULT1A1*1為96.0%，而SULT1A1*2為4.0%)，發現SULT1A1的多形性與上述各種癌的形成無關，但與年輕女性乳癌有關(P=0.012，OR = 3.35，95% CI=1.25-8.98)。

關鍵字

乳癌,多形性變異

並列摘要

Objectives. SULT1A1, the major form of cytosolic sulfotransferase enzymes (SULTs), activates or metabolizes many chemicals and carcinogens. The effect of the SULT1A1 genotype on the development of cancers is still not clear. The purpose of this study was to analyze the relationship between SULT1A1 polymorphisms and cancer risk.
Methods. We determined SULT1A1 polymorphisms by PCR-RFLP and then analyzed the frequencies of the SULT1A1*1 and SULT1A1*2 alleles from several cancerous cohorts.
Results. After analyzing 76 hepatoma patients, 180 breast cancer patients, 61 lung cancer patients, 52 oral cancer patients and 74 gastric cancer patients, the frequencies of SULT1A1*1 were 96.1%,94.2%,95.1%,96.1%,and 97.3%, respectively, whereas the frequencies of SULT1A1*2 were 3.9%, 5.8%, 4.9%, 3.9%, and 2.7% respectively. No SULT1A1*3 alleles were found in these patients.
Conclusions. In comparison with the frequencies of SULT1A1*1 and SULT1A1*2 in healthy controls (96.0% and 4.0% for SULT1A1*1 an SULT1A1*2, respectively), the allelic frequencies of SULT1A1 polymorphisms in the cancer patients were not statistically significant. However, it appears to influence the age of onset among early-onset breast cancer patients

並列關鍵字

breast cancer,polymorphism,SULT1A1