Giant cell tumors of bone are common in young adults with a peak incidence of 30 years of age. The common sites are the distal ends of the radii and knee joints. However, giant cell tumors of the hand bones are rare. Awareness of the lesion is important for correct diagnosis and treatment. A 50-year-old woman presented with a 6-month history of progressive enlargement of a mass on her left hand. Radiographs showed a markedly expansile bone lesion in the diaphyseal region of the third metacarpal. Patient age and location of the tumor cannot be used exclusively to rule out giant cell tumor. Although giant cell tumors of the bones of the hand are rare, awareness of its typical radiographic appearance are important for correct diagnosis and treatment. For patients with an obviously expansile bone lesion in metacarpals, giant cell tumor should be included in the differential diagnoses.