Class III malocclusion is common in Asian population and is a major challenge in orthodontic treatment. Some patients received orthopedic treatment to correct the skeletal disharmony in an earlier stage might have to be retreated later because of differential skeletal growth of the maxilla and mandible during the pubertal growth spurt. This article reviews some literature and discusses the craniofacial growth in Class III malocclusion. The methods and formula to predict future Class III growth pattern are also reviewed. This will help clinicians to decide whether to start camouflage treatment during the growth period or wait until completion of growth for orthognathic surgery treatment.