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The Brain Tissue Dehydration as a Mechanism of Analgesic Effect of Hypertonic Physiological Solution in Rats
並列摘要
Previously were shown that neuronal shrinkage in hypertonic solution causes the decrease of the number of functional active protein molecules in membrane having channel forming, receptor and enzyme properties. On the basis of this data the correlation between rats' brain tissue hydration and the number of ouabain receptors in membrane and pain threshold to the ”hot plate” were studied. For the estimation of brain tissue hydration the differences between wet and dry weights of tissue were measured. The number of functionally active ouabain receptors was determined by counting the number of binding labeled molecules of ouabain-3H in the brain tissue. Pain threshold was determined by means of hot plate test. Hypertonic solution caused the decrease of brain tissue hydration and the number of ouabain receptors and the increase of pain threshold. Time-dependent increase of brain tissue hydration and decrease of pain threshold were observed. On the basis of the obtained data we concluded that the pain-relieving effect of hypertonic solution is due to the decrease of the number of functionally active protein molecules in cell membrane determining its excitability.
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