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Helicobacter Pylori Infection Associated with Chronic Urticaria
並列摘要
Helicobacter pylori (H. pylori) are a gram negative bacterium, which is responsible for most cases of gastritis and peptic ulcer. It is associated with several diseases that are not related to gastrointestinal tract also. Recently, the possible association between helicobacter pylori infection and chronic urticaria (CU) is discussed in some investigations. Since the prevalence of infected persons with H. pylori and CU in Kosovo is high, the aim of this study was to evaluate correlation between the concentrations of anti-H. Pylori antibodies (IgG and IgA) and CU. The study population included 105 persons (18 - 65 Years old). With CU were diagnosed 62 of them. The diagnose was made by dermatologist and based on clinical features of CU. Blood samples were collected and analyzed for levels of serum IgG and IgA antibodies against H. pylori using ELISA method. Data were analyzed using Vassar-Stats system student's t-test for their level of significance. Results were considered statistically significant at P ＜ 0.05. From 62 patients with chronic urticaria, 44 (71%) had elevated titer of H. Pylori IgG antibodies. H. Pylori IgG plus IgA antibodies were found elevated in 47.13 % of patients, while only IgA antibodies were elevated in 43.55 % of patients. Among group without chronic urticaria we found elevated values of H. Pylori antibodies IgG in 39.6 % of patients. H. Pylori IgG plus IgA antibodies were higher than normal value in 41.9 %, while anti-H. Pylori IgA were increased in 37.4%. The value P=0.002 showed significant association between Helicobacter Pylori antibodies (IgG) and chronic urticaria. Statistically significant association (p=0.0085) was found in patients with both (IgG and IgA) elevated values too. The increased titer of IgA antibodies against H. pylori didn't show statistically significance. Based on our findings these results indicate a significant relationship of elevated concentrations of IgG and IgA antibodies against H. pylori with chronic hives, confirming the possible role of H. pylori in symptoms of chronic urticaria. Appearance of hives can be result of high level of Helicobacter Pylori IgG antibodies. An overall result of our study correlates with that by other researches.
延伸閱讀
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