Distribution of Interleukin-6 Gene Polymorphism (-174 G/C) in Head and Neck Cancer Patients in an Indonesian Population: A Preliminary Study

Frisky Amanda Putri ； Yurnadi Hanafi Midoen ； Niniarty Djamal ； Nurtami Soedarsono ； Winoto Soehartono ； Elza Ibrahim Auerkari

《Journal of International Dental and Medical Research》 10卷S期 (2017/12) Pp. 551-554

摘要

The aim of this study was to investigate whether the IL-6 (-174G/C) polymorphism is also associated with the susceptibility to head and neck cancer (HNC) in an Indonesian population. The study was conducted on Indonesian samples, with 50 samples of healthy controls and 50 samples of head and neck cancer (HNC) patients. The -174G/C polymorphism of the IL-6 gene in HNC patients and healthy controls was genotyped by the PCR-RFLP method. The genotype and allele distributions were analyzed by the chi -square test for potential association with HNC susceptibility. The GG genotype was the most common variant in the HNC and control groups, with only 2 GC genotypes found in the HNC group. No significant difference regarding the IL-6 (-174G/C) polymorphism was found between HNC patients and healthy controls. The genotype distribution of the IL-6 (-174G/C) promoter gene polymorphism showed no significant differences between the groups of HNC patients and healthy controls.

關鍵字

Interleukin 6 ； Polymorphism ； Distribution ； Head and Neck cancer ； Indonesia