An Outbreak of Coxsackievirus B5 Infection in a Nursery for the Newborn

An outbreak of coxsackievirus B5 infection among neonates occurred during October 31 to November 5, 2001. Four infants were referred from the same nursery of a maternal hospital to the sick baby room of our hospital with a diagnosis of neonatal sepsis. Another infant staying in the same sick baby room had a fever on November 7, 2001. Meningitis caused by coxsackievirus B5 was diagnosed in all 5 patients thereafier Clinical manifestations of these infants included fever, irritable crying, and lethargy. Neither the white blood cell (WBC) count nor C-reactive protein (CRP) was significantly elevated in any of the 5 patients. The WBC counts in the cerebrospinal fluid (CSF) ranged from 1 to 1505/mm^3 with lymphocytic predominance. Hypoglycorrhachia was noted in 40% (2/5) of patients. The virus was isolated from the CSF and at least 1 other site (throat, urine, or stool) in all the patients. The median duration of fever was 5.6 (range, 4~7) d. A brain sonogram performed at the acute stage revealed no brain edema. No neurological sequelae had been noted by 1 year of age. The outbreak subsided after a policy of strict hand-washing before and after contact with infants was applied in both hospitals.

並列關鍵字

coxsackievirus B5 ； infant ； meningitis ； enterovirus

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