Risk Factors for Chronic Lung Disease in Very Low Birth Weight Infants: A Five-Year Multicenter Study in Taiwan

極低體重兒慢性肺疾病之危險因子：台灣多家醫學中心五年之研究

戴碧盈(Pi-Ying Tai) ； 許瓊心(Chyong-Hsin Hsu) ； 高信安(Hsin-An Kao) ； 洪漢陽(Han-Yang Hung) ； 張瑞幸(Jui-Hsing Chang) ； 詹偉添(Wai-Tim Jim) ； 台灣早産兒聯合追蹤小組(Taiwan Infant Developmental Collaborative Study Group)

《Clinical Neonatology》 12卷1期 (2005/07) Pp. 13-18

https://doi.org/10.7098/CN.200507.0013

並列摘要

Objective: To identify risk factors for chronic lung disease (CLD) in very low birth weight infants in Taiwan.
Methods: This multicenter study enrolled 1763 infants with birth weights less than 1501 grams admitted to 8 participating neonatal intensive care units in Taiwan from 1996 through 2000. The outcome of interest was chronic lung disease (CLD), defined as dependence on supplemental oxygen at 36 weeks' postmenstrual age (PMA). The association of CLD with demographic, prenatal and illness attributes, and postnatal interventions was analyzed by the chi-square and Student's t tests. Multivariate logistic regression was used to further analyze risk factors, and odds ratios (OR) and 95% confidence intervals (CI) were estimated.
Results: Among the 1763 survivors to 36 weeks' postmenstrual age, 538 (31%) had CLD. CLD was associated with lower birth weight, lower gestational age, patent ductus arteriosus (FDA), and sepsis. When adjusted for birth weight, small for gestational age (SGA) associated with a significantly reduced risk of CLD, but when adjusted for gestational age, SGA was associated with a slightly increased, but statistically non-significant, OR for CLD.
Conclusion: Low birth weight, low gestational age, FDA and sepsis were associated with an increased risk of CLD.

並列關鍵字

chronic lung disease ； bronchopulmonary dysplasia ； risk factors ； very low birth weight ； small for gestational age