Anaerobic mesophilic fermentation of sulphate containing yeast industry wastewaters at laboratory scale with anaerobic sequence batch reactors (ASBR) was studied. Three different treatment schemes were investigated-ASBR with and without a polymeric filler and coupled micro-aerophilic/anaerobic SBR (CSBR). The optimal concentration of sludge (total solids 17.3g L^(1)) in the reactor and the optimal reaction time (22h) were determined. It was shown that in the case of ASBR efficient treatment characterized by chemical oxygen demand (COD) removal of 75-82% took place at volume loading rates up to 7.7-8.0kgCOD m^(-3) d^(-1) and at COD/(SO4) (superscript 2-) ratio 8.0. In optimal conditions the methane content of the biogas was 60%. The best results for sulphate removal (99%) were achieved in the CSBR with the concentration of sulphide in the reactor effluent being about 10mg L^(-1). Decreasing treatment efficiency after a long-time exploitation of these reactors occurred as a result of the formation of insoluble sediment (presumably CaCO3 and Ca3(PO4)2).