For an orthodontic case with the discrepancy of the discoordination between the length of palate bone and tooth size or for a case with skeletal discrepancy of the unsymmetry upper and lower jaw in their size and position, the most common treatment is to extract the upper ahd lower first or the second premolar. But in some special cases olny four first premolar or two first premolar: two 2nd premolar extraction cannot lead to a good result.In these case, another four first molars extraction is a good choice to reach a good mesial and distal relationship between upper and lower molar area and get a good profile.This article is a report of sever maxillary protrusion or bimaxillary protrusion cases. They had four first premolar extraction, but the outcomes were not so satisfied. So four first molars were extracted later, and this contributed to a good profile.