This case study reported the nursing experience for a patient with acute compartment syndrome secondary to rhabdomyolysis at the intensive care unit. The period of nursing care was from December 1 to December 18, 2007. With Roy's adaptation model, nursing problems were identified through direct patient care, case interview, and physical examination. The addressed nursing diagnosis were impaired skin integrity, risk for infection, altered tissue perfusion, and post-trauma response. Nursing interventions included wound care, control of body temperature, prevention of infection, and elevation of affected body parts for promotion of circulation and healing. This article offered nurses a reference for caring for a patient with acute compartment syndrome secondary to Rhabdomyolysis.