Due to the requirement of the graded system for aging society in terms of acute medical care, chronic diseases and long term care for patients. The integrated care team usually needs to provide seamless transitional care for palliative and multi-morbid patients when preparing inpatient discharge. At present dedicated discharge transfer team has already been developed in many hospitals; while phone tracking of high-risk discharged patients of nursing staff has been established in the past. Furthermore, nurse as an important member of the integrated care team can also play an important role as coordinator and case manager when assists patients in smoothing transfer process in between medical care teams. This article provides the experience of the transitional care nurse from a graded medical center, by sharing three different types of referral cases in the medical center, and hence provided the clinical guidance for transitional care in the future.