As the Coronavirus Disease-2019 (COVID-19) pandemic emerged across various countries, healthcare systems are facing unprecedented burdens. The pandemic has continued to intensify the availability, accessibility, quality, safety of healthcare systems, and has hence distinguished the safety management for patients and healthcare workers. The successful experience of epidemic prevention lies in its sufficiently adequate preparation and reaction from its healthcare system, which demonstrate the adaptability and flexibility of the national-wide healthcare system can response better along with lifesaving. Constructing a resilient healthcare system, the concepts of Resilience and Safety II, as well as policies regarding patient safety; that enable effective prevention initially and timely response from the healthcare system are extremely important subjects.