The vibration response of isotropic and orthotropic plates with mixed boundary conditions is numerically modeled using a solution that is based on the differential quadrature method (DQM). The DQM is applied to each region and with the imposition of appropriate boundary conditions; the problem is transformed into a standard eigenvalue problem. The δ technique is used to treat the various boundary conditions. The results also demonstrate the efficiency of the method in treating this class of engineering problem.