維生素D對中重度憂鬱症之效益：系統性文獻回顧及統合分析

EFFICACY OF VITAMIN D FOR MODERATE OR SEVERE DEPRESS ION: SYSTEMATIC REVIEW AND META-ANALYSIS

董玲吟(Ling-Yin Dong) ； 邱百誼(Pai-Yi Chiu) ； 林君宜(Chun-Yi Lin) ； 李銘宗(Ming-Tsung Lee)

《秀傳醫學雜誌》 17卷1期 (2018/06) Pp. 59-64

https://doi.org/10.3966/156104972018061701008

摘要

背景：基於維生素D對憂鬱潛在治療角色，且相關研究尚未有一致的結果。目的：本研究旨在透過系統文獻回顧及統合分析，探討維生素D針對中重度憂鬱患者之憂鬱症症狀改善功效。方法：搜尋PubMed、中文電子期刊服務資料庫（Chinese Electronic Periodical Services, CEPS），以設定的關鍵字進行文獻搜尋，共納入3篇隨機對照實驗研究。研究品質以Cochrane提供的隨機對照實驗風險偏誤評量做評讀，使用RevMan 5.3進行統合分析，療效指標為貝克憂鬱量表平均分數及標準差。結果：維生素D有效改善憂鬱症狀，其綜合效果量為-0.40（95% CI: -0.69, -0.11）。結論：補充維生素D對治療中重度憂鬱症患者之憂鬱程度有一定療效，然用藥之安全性，仍須大型臨床試驗加以證實。

關鍵字

維生素D ； 憂鬱症 ； 效益 ； 系統性文獻回顧 ； 統合分析

並列摘要

Background: Previous studies have identified potential benefits of vitamin D for depression; however, controversial results still exist. Purpose: The aim of this study was to identify the potential benefits of vitamin D for depression by a systematic review and meta-analysis. Methods: Studies were retrieved from PubMed and Chinese Electronic Periodical Services using preset keyword searches. Three randomized controlled trials were included. Assessment of risk of bias used the Cochrane collaboration checklist for RCT. Meta-analysis was performed using Review Manager 5.3. Mean and standard deviation of the Beck Depression Inventory scores were taken as indexes of efficacy. Results: Vitamin D supplements effectively improve depressive syndromes. The effect size among these randomized controlled trials was -0.40 (95% CI: -0.69, -0.11). Conclusions: W e found a significant difference in the efficacy of vitamin D for depression. However, it is concluded that before widely using vitamin D, a large randomized controlled trial is warranted to study the safety of vitamin D.

並列關鍵字

Efficacy ； Vitamin D ； Depression ； Systematic review ； Meta-Analysis