Bilateral medial medullary infarction (BMMI) is very rare. Typical clinical manifestations of this disease are bilateral hypoglossal nerve palsy, tetraparesis, and the disturbance of deep sensations. It can also be life-threatening due to acute respiratory failure, and is a particularly stressful situation for emergency physicians when dealing with this. A characteristic ”heart” sign is a diagnostic finding with horizontal diffusion-weighted MRI sections. The use of timely thrombolytic therapy with vertebrobasilar recanalization in patients carries a high mortality rate. However, patients with respiratory failure would survive if the occurrence of a stroke is immediately recognized, and the patient is treated with ventilator support.