Feminism has criticized androcentrism-based science since 1970s, due to being aware of the inevitable intertwinement between knowledge development and power, culture, and value. Therefore, a unique epistemology to guide the constructing of knowledge was developed, and feminist research started to emphasize a non-hierarchical, reflexive, and interactive approach, thriving for a social reform. This article examined feminist epistemology, feminism and nursing knowledge development, feminist methodology and the methods in application. The feminist approach is concerned not only in making women visible, but also with theoretical and methodological issues, and is believed to offer a valuable and insightful way in which to influence nursing science development.