質子治療的發展與臨床應用

癌症已是全球主要死因的疾病之一，隨著醫療治療科技發展，精準化優勢治療重點在命中治療標的，降低治療副作用，提升癌症病人生活品質。放射治療是癌症病人重要治療方式之一，常因放射線產生正常組織急性損傷及長期損傷。質子治療（Proton Therapy）具備抗癌治療精準特性，治療原理為利用質子射束具備的布拉格峰（Bragg Peak）物理特性，讓大部分射線能量集中於腫瘤，降低靠近腫瘤的重要器官或組織傷害，減少因治療產生副作用的風險，達到精準抗癌治療的目標。2015年11月，台灣第一個質子治療中心於林口長庚醫院啟用；而2022年7月，大台北地區首座質子治療中心於臺北醫學大學附設醫院啟用，北醫質子中心是台灣第一台超導型加速器質子治療機，展現出質子治療優勢，北醫質子中心第一例病人為兒癌患者，更打破傳統放射治療年齡限制，完成年僅10個月大的小腦惡性腫瘤病童治療，透過質子治療優勢，讓病人獲得治療成效及維持生活品質。整體而言，質子治療提供精準新穎的抗癌治療選擇，以期達到腫瘤控制同時延長有品質的存活。

關鍵字

癌症治療；質子治療；護理照護

並列摘要

Cancer is a leading cause of death worldwide, according to World Health Organization reported, accounting for nearing 10 million deaths in 2020. The key point of precision anti-cancer therapy is to give effectiveness of treatments that are most likely work, while avoiding giving side-effects and complications. Radiotherapy is commonly used in cancer care, but may cause acute- and long-term toxicities as an effects of radiation deposition in normal tissues surrounding cancer cell. Proton therapy making use of the characteristic Bragg Peak, can be delivered with precise energies to a desired depth and depositing energy. These advantages of proton therapy have demonstrated improve clinical outcomes and reduced side effects of therapy, as well as reserve better physical performance status and quality of life. In November 2015, the first Proton beam therapy center set up in Linkuo Chang Gung Memorial Hospital in Taiwan. The proton therapy center of Taipei Medical University Hospital (TMUH) is Taiwan’s first proton machine with superconducting cyclotron, set up in the prosperous downtown of Taipei in July 2022. After the very first patient with pediatric cancer treated in TMU proton center, more and more patients with advanced disease received proton therapy in TMU proton center. Proton therapy is a promising treatment option, which provide the effectiveness of radiation energy to be more concentrated and released at the tumor site, and reduce the damage at the normal tissues near the tumor.

並列關鍵字

Anti-Cancer treatment ； Proton therapy ； Nursing care

參考文獻

王駿瑋（2020）‧質子治療在頭頸癌之發展與應用‧台灣醫學，24（5），542-548.DOI:10.6320/FJM.202009_24(5).0007

林文瑛（2020）‧麻醉在質子治療中的重要性‧台灣醫學，24（5），563-566.DOI:10.6320/FJM.202009_24(5).0010

林士敏、張東杰（2016）‧質子放射治療在乳癌之應用‧中華民國內膜異位症婦女協會會刊，23（7&8），20-21.DOI: 10.6498/EA.2016.23(07/08).7

陳育瑄、郭頌鑫（2013）‧乳癌的放射治療‧台灣醫學，17（4），390-396.DOI:10.6320/FJM.2013.17(4).06

周繡玲、謝嘉芬、李佳諭、江孟冠、紀雯真（2011）‧癌症病人口腔黏膜炎臨床照護指引‧腫瘤護理雜誌，11，61-85.DOI:10.6880/TJON.201112/SP_11.05

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