Advances in technology and the effectiveness of clinical cancer treatments significantly increased cancer survival rates. However, these treatments have induced cancer-related fatigue and other complications that result in long-term deleterious physiological and psychological conditions in cancer survivors. Researchers have indicated that exercise intervention could reduce some cancer related syndromes and increase quality of life during and after treatments in cancer survivors. In this review, we indicated the possible mechanisms of the effectiveness of exercise intervention during and after cancer treatments, and compared outcomes from these intervention. The results revealed that effectiveness of exercise intervention would be different. Exercise workload should be mild to moderate according to the health of cancer survivors. Further research should explore the possible interactive mechanism between exercise intervention improvements and cancer treatments, so as to encourage the cancer survivors and to maintain their motivation to participate in exercise interventions to obtain better rehabilitative effectiveness.