【論文摘要】Circulating MicroRNAs Response After Exercise-Induced Muscle Damage

【論文摘要】運動誘發肌肉損傷對於循環性小分子核醣核酸的影響

林政憲(Cheng-Hsien Lin) ； 黃瑾慧(Ching-Hui Huang) ； 王鐘賢(Jong-Shyan Wang)

《物理治療》 43卷2期 (2018/06) Pp. 132-133

https://doi.org/10.6215/FJPT.2018.75.O17

摘要

Background and Purpose: Intense exercises lead to decreasing muscle strength, thus depressing exercise performance. Circulating microRNAs (c-miRs) may control muscle synthesis and recovery following intense exercises. Our study aimed to find the relationships between c-miR responses and muscular fatigue after the exercise-induced muscle damage test. Methods: Fifteen healthy sedentary males were enrolled, and then involved the exercise-induced muscle damage test (i.e., quadriceps muscle concentric and eccentric contractions to fatigue) in isokinetic dynamometry. The levels of various c-miRs stand for inflammatory thrombosis (miR-21, miR- 150), muscular damage (miR-146a, miR-499a), and vascular endothelial function (miR-221, miR-222) were measured by quantitative real time polymerase chain reaction (qRT-PCR), individually. Results: Our results showed that the concentrations of miR-21, miR-150, miR-146a, miR-499a, miR-221, and miR- 222 in plasma were significantly increased 4 h after the exercise-induced muscle damage test. Nevertheless, the levels of muscular fatigue-related c-miRs reversed back to the baseline 24 h after the exercise-induced muscle damage test. Conclusion: Consequently, we conclude that the c-miRs related to inflammatory thrombosis, muscular damage, and endothelial function may serve as the novel indicators of muscle damage caused by the exercise-induced muscle damage test. Clinical Relevance: Our results provide important information to help rapid screening for individual muscle-fatigue characteristics.