Background and Purpose: Baseball pitching generates large forces in the throwing shoulder. The repetitive pitching at high velocities over time leads to chronic adaptions to soft and osseous tissues in glenohumeral range of motion (ROM), which may increase the risk of injury to upper extremity joint. Therefore, the purpose of this study was to identify associations collegiate between pitchers with glenohumeral internal rotation deficit (GIRD) and upper extremity injury in collegiate baseball pitchers. Methods: A total of thirty baseball pitchers with GIRD underwent a comprehensive preparticipation physical health status examination. Passive ROM measurements were recorded using a customized standard gonimeter for shoulder external rotation (ER), internal rotation (IR), total rotation motion (IR + ER) on the dominant and nondominant arms, and associations with previous injuries were identified. GIRD as defined is a loss of IR of the throwing shoulder of 20° or more as compared with the nonthrowing shoulder. Results: There was a history of elbow injuries or complaints in 70% of pitchers; the most common diagnosis was ulnar collateral ligament tear (36.37% of pitcher). Two pitchers had been diagnosed tennis elbow (6%), Nine pitcher (30%) had suffered shoulder pain in the past. Five pitchers had been diagnosed with rotator cuff tear (16.67%). Three pitchers had been diagnosed as the subacrominal impingement (10%). Conclusions: We report pitchers with GIRD could potential risk factor for elbow and shoulder injury. GIRD may be associated with an ulnar collateral ligament tear in collegiate baseball pitchers. Clinical Relevance: Early detection, proper assessment techniques and various IR-flexibility program are important to prevent GIRD.