Background and Purpose: The effect of edema control by different methods is not clear. The objective of this study is to investigate the reliability of measuring severity of edema using ultrasound (USD) imaging, and to compare the effect of manual lymph drainage (MLD) technique, epidermis taping technique, and self-massage on edema control. Methods: Nineteen subjects with unilateral lymphedema were recruited. Subjects were randomized to three groups including MLD, epidermis taping and self-massage groups. Subjects' circumference (8 sites) and USD (6 sites) of the affected upper extremity were measured using tape-measurement and ultrasonography respectively. Results: USD showed good reliability (intraclass correlation coefficient [ICC] = 0.885) in measuring subcutaneous thickness. Significant difference in circumference before and after treatment was found in all three groups (p < 0.05). One-way analysis of variance (one-way ANOVA) showed a significant group effect on mean differences of circumference [F(2,81.956) = 8.53, p < 0.01]. Post-hoc comparisons using the Games-Howell test indicated that the mean difference for the taping group (mean [M] = 0.84, standard deviation [SD] = 0.96) and the MLD group (M = 0.66, SD = 0.47) were significantly higher (p < 0.05) than the self-massage group (M = 0.27, SD = 0.53). However, no significant difference (p > 0.05) was found between the taping group and the MLD group. Conclusion: Ultrasound is a reliable tool for measuring subcutaneous thickness. It is also found that all taping, MLD and self-massage could successfully decrease limb circumference, though taping and MLD were more effective than self-massage. Clinical Relevance: Taping could replace MLD treatment.