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【論文摘要】Effect of Family-Centered Intervention on the Quality of Life in Mothers of Preterm Infants With Very Low Birth Weight

【論文摘要】以家庭為中心早期介入對極低出生體重早產兒母親生活品質之影響

摘要


Background and Purpose: Preterm infants with very low birth weight (VLBW, birth weight < 1,500 g) have higher risk of health problems and developmental disorders than term infants. Mothers of preterm infants with VLBW often encounter challenge and pressure in interaction and child care that may have a negative impact on their quality of life. Early intervention has been found to yield developmental benefits in preterm infants, however the effect on maternal quality of life has rarely been examined. Therefore, the aims of this study were to investigate the effect of a family-centered intervention program (FCIP) on the quality of life in mothers of preterm infants with VLBW with respect to a usual care program (UCP), and to examine whether mother-infant interaction mediated intervention effect on maternal quality of life. Methods: This multi-site randomized controlled study included 224 VLBW preterm infants without severe perinatal complications (113 in the FCIP group and 111 in the UCP group) that the intervention lasted from hospitalization to 12 months of corrected age. All mothers completed the brief Taiwanese version of World Health Organization Quality of Life questionnaire (WHOQOL-BREF) at term, 12 and 24 months of corrected age. The quality of mother-infant interaction was examined in a 6-min free play procedure when infants were at 6 and 12 months of corrected age. Results: The FCIP-group mothers showed significantly higher physical subscores of the WHOQOL-BREF than the UCP-group mothers across ages (term: 13.5 ± 2.2 vs. 12.9 ± 2.4; 12 months: 13.9 ± 2.0 vs. 13.5 ± 2.2; 24 months: 13.9 ± 2.2 vs. 13.8 ± 2.2, p < 0.05). No group difference was found for the psychological, social and environmental sub-scores. Furthermore, mediator analyses revealed that adding the mother discordant pattern at 6 months of corrected age had attenuated the intervention effect on physical domain scores of the WHOQOL-BREF. Conclusion: The FCIP benefits the physical aspect of quality of life in mothers of preterm infants with VLBW. Furthermore, the effect on physical domain scores appeared to be mediated via enhanced motherinfant interaction. Clinical Relevance: Our results provide important information for the design of effective intervention program for preterm children with VLBW and their mothers in Taiwan.

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