運動壓力對自然殺手細胞數量及皮質醇之影響

The Effects of Exercise Stress on Natural Killer Cell Counts and Cortisol Concentration

張玉佩(Yu-Pei Chang) ； 曾玉珍(Yu-Jane Tzeng) ； 徐廣明(Kuang-Ming Hsu) ； 徐台閣(Tai-Ger Hsu)

《大專體育學刊》 8卷2期 (2006/06) Pp. 219-229

https://doi.org/10.5297/ser.200606_8(2).0019

摘要

The high intensive training induces temporary immunosuppression, and exercise stress is also a factor. Natural killer cells are important components of the innate immune system, owing to their cytokine production and cytolytic activity against the target cells. To investigate the natural killer cell counts and the stress hormone cortisol concentration after high strength exercise, twelve subjects (VO2(subscript max) above 60mL/kg/min) participated in this study. Blood samples were collected from each of the subjects who had consecutively performed 3 days of high-intensity exercise (at 85% VO2(subscript max)) on the following schedule: 3 days before exercise, after the first day of exercise, after the second day of exercise, and after the third day of exercise, 24 hours after the exercise, and 72 hours after the exercise. The blood sample of NK cell counts and cortisol concentration were measured by Flow Cytometry and the enzyme- linked immunosorbent assay. The results of this study was that NK cell counts and cortisol concentration always increased after each running and recovered 24 hours later. That may be a postive correlation between the expression of NK cell counts and plasma cortisol concentration. In conclusion, the short-term high intensity exercise training was associated with significant NK cell counts inducted by cortisol of exercise stress.

關鍵字

運動壓力 ； 自然殺手細胞 ； 皮質醇

並列摘要

The high intensive training induces temporary immunosuppression, and exercise stress is also a factor. Natural killer cells are important components of the innate immune system, owing to their cytokine production and cytolytic activity against the target cells. To investigate the natural killer cell counts and the stress hormone cortisol concentration after high strength exercise, twelve subjects (VO2(subscript max) above 60mL/kg/min) participated in this study. Blood samples were collected from each of the subjects who had consecutively performed 3 days of high-intensity exercise (at 85% VO2(subscript max)) on the following schedule: 3 days before exercise, after the first day of exercise, after the second day of exercise, and after the third day of exercise, 24 hours after the exercise, and 72 hours after the exercise. The blood sample of NK cell counts and cortisol concentration were measured by Flow Cytometry and the enzyme- linked immunosorbent assay. The results of this study was that NK cell counts and cortisol concentration always increased after each running and recovered 24 hours later. That may be a postive correlation between the expression of NK cell counts and plasma cortisol concentration. In conclusion, the short-term high intensity exercise training was associated with significant NK cell counts inducted by cortisol of exercise stress.

並列關鍵字

exercise stress ； natural killer cell ； cortisol

參考文獻

Greenspan, F. S.(1991).Medicine, and Chief, Thyroid Clinic.San Francisco:University of California.

Hoffman-Goetz, L.(1996).Exercise and immune function.United States of America:CRC Press.

Richard, A. G.,Thomas, J. K.,Barbara, A. O.(1992).Kuby immunology.New York:W. H. Freeman and Company.

Shephard, R. J.(1997).Physical activity, training and the immune response.Carmel, IN:Copper Publishing Group.

Greenspan, F. S.(1991).Basic and clinical endocrinology.University of California:San Francisco, Medicine, and Chief, Thyroid Clinic.