年齡對運動誘發固醇類荷爾蒙反應之影響：脫氫異雄固酮所扮演的角色

Effects of Age on Exercise Response in Steroid Hormones: Role of DHEA-S

陳九州(Chiu-Chou Chen) ； 陳宗與(Chung-Yu Chen) ； 侯建文(Chien-Wen Hou) ； 王韻嘉(Yun-Chia Wang) ； 劉德智(Te-Chih Liu)

《大專體育學刊》 14卷4期 (2012/12) Pp. 500-511

https://doi.org/10.5297/ser.1404.011

摘要

脫氫異雄固酮（dehydroepiandrosterone, DHEA）是許多固醇類荷爾蒙的共同前驅物，隨年齡增加而減少。本研究目的為探討老化對於120秒單次高強度腳踏車運動挑戰後固醇類荷爾蒙反應之影響，以及脫氫異雄固酮所扮演的角色。11名受試者包括年輕（n = 5，21.0 ± 0.4 歲）與中年男性（n = 6，48.3 ± 2.5 歲）；在補充脫氫異雄固酮（50 mg）後12小時接受120秒，強度為100%攝氧量峰值（V O2peak）之單次腳踏車運動挑戰。血中脫氫異雄固酮─硫酸鹽、乳酸、總睪固酮、游離睪固酮、促黃體生成激素（luteinizing hormone, LH）及可體松（cortisol） 濃度分別於運動挑戰前與第120秒後收集血液樣本並分析；結果顯示：本研究之120秒運動挑戰後使受試者之血乳酸濃由0.65 mM上升達到12 mM，但總睪固酮與游離睪固酮濃度在運動後均未顯著提高；單次補充50 mg之脫氫異雄固酮雖對運動過程第120秒總睪固酮濃度無明顯提升效果，但能提高游離睪固酮濃度。單次補充脫氫異雄固酮後12小時即可使兩年齡組血中脫氫異雄固酮─硫酸鹽與游離睪固酮濃度顯著升高，並且使中年男性血中游離睪固酮濃度達到年輕組之水準，而脫氫異雄固酮─硫酸鹽濃度更高於年輕男性3倍。中年組之促黃體生成激素明顯較年輕組高。中年補充脫氫異雄固酮組雖明顯提高了游離睪固酮濃度，但對於促黃體生成激素的濃度無明顯影響，且在運動挑戰後亦無法明顯提高促黃體生成激素濃度。本研究結論：在腳踏車測功儀進行高強度間歇單次運動過程後，雖增加血乳酸達18倍，但無法增加血睪固酮濃度；本研究發現年齡較高者男性促黃體生成激素濃度相對較高可能與游離睪固酮有關。此外，提高脫氫異雄固酮─硫酸鹽濃度並無法改變運動後所有固醇性荷爾蒙的反應。

關鍵字

中年 ； 乳酸 ； 睪固酮

並列摘要

DHEA, the common precursor of many steroid hormones, declines with advancing age. This study examined the effects of age on exercise response in steroid hormones. Eleven volunteers, including 5 young (21.0 ± 0.4 years) men and 6 middle-aged (48.3 ± 2.5 years) men, were supplemented with a single dose DHEA (50 mg) or placebo, 12 h before an 120-s of exercise challenge on a cycloergometer at 100% V4 O2max. Blood DHEA-S, lactate, testosterone, free testosterone and cortisol levels were measured before and after exercise challenge. Exercise significantly elevated the lactate levels from 0.65 to 12 mM immediately after cycling for both young and middle-aged subjects. However, total and free testosterone levels were not significantly changed after the 120-s high intensity cycling exercise. A single dose DHEA supplementation significantly affected free testosterone in parallel with a 3-fold elevation in DHEA-S concentration for the middle-aged subjects to that of the youth level. Luteinizing hormone (LH) levels in middle-aged subjects were significantly greater than that in the young subjects. Despite DHEA supplementation elevated free testosterone levels, LH levels remained unaffected. Furthermore, exercise has no significant effect on LH levels. Conclusion: Despite lactate levels increased by 18-fold, exercise was unable to increase testosterone levels. Additionally, we found elevated LH levels in middleaged subjects may be associated with reduced free testosterone. Furthermore, increasing DHEA-S could not affect exercise response to steroid hormone.

並列關鍵字

middle-aged ； lactate ； testosterone

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