口服去氫羥化腎上腺皮質素對運動表現及尿液藥檢之影響

Effect of Prednisolone on Sport Performance and Urine Doping Test

林勁宏(Ching-Hung Lin)

《大專體育學刊》 16卷3期 (2014/09) Pp. 321-332

https://doi.org/10.5297/ser.1603.006

摘要

本研究目的探討口服低劑量去氫羥化腎上腺皮質素（prednisolone）後接續運動，尿液中prednisolone的濃度，同時也分析口服prednisolone對中強度運動表現的影響。以7名有運動習慣的健康男性（年齡19.6 ± 1.0歲；身高170.1 ± 2.8公分；體重65.5 ± 2.3公斤）為研究對象，每位受試者接受三種實驗處理，第一種實驗為口服5毫克prednisolone混合400毫克麥芽糊精試劑後，觀察24小時間prednisolone從尿液中排出的濃度（Pred組），第二、三種實驗分別口服400毫克麥芽糊精之安慰劑或5毫克prednisolone混合400毫克麥芽糊精試劑後，接續以70% VO_2max之強度運動至力竭（運動安慰劑組及運動Pred組），除觀察兩組運動力竭時間，呼吸生理及血液生化值外，也分析24小時間prednisolone從尿液中排出的濃度。研究結果：運動Pred組之24小時內排出prednisolone的濃度與Pred組皆無顯著差異，但在12小時的觀察點時，運動Pred組尿液中prednisolone的平均濃度仍高於30 ng/ml的陽性違規閾值。而運動安慰劑與運動Pred組在運動力竭時間等部分觀察指標皆無顯著差異，但運動安慰劑組的游離脂肪酸濃度，在運動中第15分鐘顯著低於運動Pred組，以及血糖濃度在運動中第45、60分鐘與力竭點也明顯低於運動Pred組。研究結論：本研究主要發現運動不會縮短口服單次低劑量之prednisolone從尿液中排出的時間，且12小時之後尿液檢體濃度很有可能仍超過違規的閾值，同時也無法增加中強度運動持續的時間。

關鍵字

血糖 ； 游離脂肪酸 ； 碳水化合物 ； 脂質

並列摘要

The purpose of this study was to investigate that the effect of oral administration of prednisolone (Pred) on the changes of urine Pred concentrations following a single bout of exercise and to determine the sport performance in young men. Seven healthy male volunteers (age, 19.6 ± 1.0 yr; height, 170.1 ± 2.8 cm; weight, 65.5 ± 2.3 kg) with regular exercise activities were participated in this study. All subjects were undertaken three different treatment trials. In the first trial, subjects received 5 mg Pred with 400 mg maltodextrin, and then urine Pred concentration was estimated during 24 hours (PredC). In the second and third trials, subjects were assigned into either placebo (400 mg maltodextrin) with exercise (PLE) or Pred (5 mg plus 400 mg maltodextrin) with exercise (PredE) trials. A 70% VO2max endurance exercise test to exhaustion was performed immediately after supplementation. Respiratory related markers, blood sample and 24 hours urine prednisolone concentrations were measured. The results showed that there was no significant difference in the urinary Pred concentration between PredC and PredE trials during 24 hours. The urinary Pred concentration in PredC trial at 12 hours was below 30 ng/ml, while, it was above 30 ng/ml in PredE trial at the same time point. No significant differences in respiratory related markers, rate of energy utilization and exercise time to exhaustion were observed between PLE and PredE trials. The concentration of blood free fatty acid at 15 min during exercise was significantly lower in PLE than PredE trial. The blood glucose level in PLE was significantly lower than PredE trial at 45 min and 60 min during exercise, and also immediately after exercise. The main finding of this study was that sub-maximal exercise may not accelerate urinary elimination rate of Pred, and may cause positive test result after 12 hours in young men. Besides, ingestion of low-dose Pred could not increase the time to exhaustion during the sub-maximal exercise test.

並列關鍵字

blood glucose ； free fatty acid ； carbohydrate ； lipid

參考文獻

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