Oropharyngeal and swallowing functions often compromised after oral endotracheal intubation. Because oral intake is an important component of patient recovery after critical illness, the aim of this paper was to briefly review the impacts of prolonged endotracheal intubation on oropharyngeal and swallowing functions. Effects on dry mouth, impaired somatosensory functions, laryngeal injury, orofacial muscle weakness and temporomandibular joint disorder, impaired airway protection, impaired coordination of breathing and swallowing, and altered swallowing function are presented. In keeping with previous research, we defined prolonged endotrachel intubation as 48 hours and longer. We hope by increasing the awareness among professionals, early detection and timely intervention could be taken to manage oropharyngeal and swallowing functions for patients with prolonged endotrachel intubation.