利用大白鼠動物試驗模式探討真珠草萃取物對於急性化學性肝損傷的預防與保健之功效

The Efficacy Test of Protection and Treatment of a Phyllanthus Extract Against the Chemical-induced Liver Damage in Rat Animal-models

廖朝暐(Chao-Wei Liao) ； 張文發(Woon-Fa Chang) ； 顧錦國(Jerro Koo)

《臺灣農業化學與食品科學》 44卷6期 (2006/12) Pp. 370-381

https://doi.org/10.6578/TJACFS.2006.043

摘要

This study examined the effect of phyllanthus hepatoprotective and detoxifying actions on chloroform or acetoaminophen-induced damage in rat animal models. After administered with Phyllanthus urinaria extract each day by oral gavage for 3 weeks, the rats were then intra-peritonially injected twice with chloroform or acetoaminophen on the first and fourth day of the fourth week. The protection experiment of those chemical liver-damage treatments was then observed and evaluated for the fallowing next three weeks. Another experiment for therapeutic treatment test, the rats were previously intra-peritoneally injected twice with chloroform or acetoaminophen at the first and fourth week, then orally administered with phyllanthus extract everyday at the 2nd, 3rd, 5th and 6th week. The detoxification effect was investigated for the following next two weeks. From the data of rat liver damage and histopathological finding, mortality, vitality, and weight gain showed that the high-dosage group (150 mg/kg/day) of phyllanthus extract had a statistically significant (p＜0.05) both precaution and treatment on the detoxification against chemical toxicity.

關鍵字

真珠草 ； 肝損傷 ； 三氯甲烷 ； 乙醯胺酚 ； 保肝

並列摘要

無資料

並列關鍵字

Phyllanthus urinaria ； Liver damage ； Chloroform ； Acetoaminophen ； Hepatoprotective