摘要
香豆素（coumarins）為植物重要的二級代謝產物，具有生理活性對人體健康有助益。香豆素為植物特有的多酚類化合物，主要存在於繖形花科（Apiaceae）及芸香科（Rutaceae）植物中，其中部分植物已成為人類日常生活食用之香料及蔬菜。香豆素由類苯基丙烷代謝路徑生合成，主體結構為一苯環加上一吡喃酮，藉此衍生出各種香豆素。香豆素衍生物具有抗發炎、抗菌、抗癌及美白等多種功效。在醫學上，利用香豆素之光敏性治療皮膚性疾病，或利用化學合成方式將香豆素衍生為抗凝血用藥。除此之外，香豆素亦廣泛應用於多種商業用途。由於生物食入會造成體內解毒酵素cytochorme P450活性增加，因此被認為具毒害性質。未來香豆素之保健功能與毒害作用如能再進一步研究釐清，並將其相關植物進行加工多元化利用，將可提高植物之利用價值。
並列摘要
Coumarins are one of the plant secondary metabolites demonstrated to have physiological activities on human health. They belong to one of the plant specific polyphenolic compounds found primarily in Apiaceae and Rutaceae. Several of these plants are used as spices and vegetables in the human diet. Coumarins are synthesized from the phenylpropanoids pathway, all of which consist of a benzene ring joined to a pyrone and various complex coumarins are derived. Coumarin derivatives have many bioactive effects, such as anti-inflammatory, anti-bacterial, anti-cancer, whitening and other effects. In the pharmaceutical industry, coumarin therapy is used for skin diseases due to its photosensitivity, while chemically synthesized coumarin derivatives are utilized in anti-clotting medication. Coumarins also have many commercial applications. Since coumarin causes cytochrome P450 activity to increase when insects ingest it, it is considered toxic to organisms. The health benefits and toxic effects of coumarins to humans should be clarified and the development of diversified processing products in the future will enhance the value of the plants.
延伸閱讀
- 盧凌、王仁宗、張榮錡、王金漢、莊昭文、陶占瑞（2000）。香豆素衍生物的應用。化學，58(3)，367-385。https://doi.org/10.6623/chem.2000040
- 張志邦（2004）。四羥基香豆素衍生物之合成及抗菌〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714563095
- 蘇柳青、朱華、李樹其（1990）。香草香料中香豆素含量之調查。藥物食品檢驗局調查研究年報，()，157-158。https://doi.org/10.6946/ASRNL.199009.0157
- KIM, Y. C., & SRIVASTAVA, H. M. (1999). SOME APPLICATIONS OF A DIFFERENTIAL SUBORDINATION. International Journal of Mathematics and Mathematical Sciences, 1999(), 649-654. https://doi.org/10.1155/S016117129922649X
- Wong, F. T. (1969). Substitutions of four-coordinated complexes [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200015431