本研究目的為比較感音神經性聽力損失(聽損)成人500及4000 Hz的聽性腦幹反應(auditory brainstem response, ABR)及中潛時反應(auditory middle-latency response, AMLR)閾值與純音(pure tone)聽閾之相關性。參與研究個案有17名聽損者,年齡範圍介於25到60歲,其中測試純音聽閾於500及4000Hz為40至80 dB hearing level(HL),此研究共計20耳,各測試耳之鼓室圖呈現Type A。研究結果顯示20耳所測得500及4000 Hz兩頻率之ABR閾值與純音聽閾的平均差異分別為6.0及6.3 dB,標準差分別為7.8及6.6 dB;在500及4000 Hz兩頻率中AMLR閾值與純音聽閾的平均差異分別為3.6及2.3 dB,標準差分別為6.1及7.0 dB;在500及4000 Hz兩頻率中ABR閾值與AMLR閾值的平均差異分別為2.3及4.0 dB,標準差分別為5.9及6.8 dB。聽損受試者純音聽力檢查於500及4000 Hz之ABR閾值,相關係數(r)分別為0.83及0.87;聽損受試者純音聽力檢查於500及4000 Hz之AMLR閾值,相關係數分別為0.90及0.85。使用單因子變異數分析事後多重比較檢定法分析純音聽閾、ABR及AMLR之閾值顯示刺激音在500或4000 Hz時,三者間皆無顯著差異(p > 0.05)。整體而言,本研究顯示當刺激音為500及4000 Hz短爆音(tone bursts)時,ABR閾值及AMLR閾值與純音聽閾均達高度相關性。建議以500及4000 Hz短爆音為刺激音所測得ABR閾值與AMLR閾值,可用來預估聽損者之聽覺敏感度。
The purpose of this study is to compare threshold measures with auditory brainstem response (ABR), auditory middle-latency response (AMLR) to tone bursts of 500 and 4000 Hz, and pure tone audiometry. Seventeen participants aged 25 to 60 years old exhibited pure tone thresholds ranging from 40 to 80 dB hearing level (HL) at 500 and 4000 Hz, as well as Type A tympanograms. The results indicated that the mean differences between ABR and pure tone thresholds of 500 and 4000 Hz were 6.0 and 6.3 dB, respectively; standard deviations were 7.8 and 6.6 dB, respectively. The mean differences of AMLR and pure tone thresholds of 500 and 4000 Hz were 3.6 and 2.3 dB, respectively; standard deviations were 6.1 and 7.0 dB, respectively. The mean differences of ABR and AMLR thresholds of 500 and 4000 Hz were 2.3 and 4.0 dB, respectively; standard deviations were 5.9 and 6.8 dB, respectively. The analysis among thresholds of pure tone, ABR and AMLR for 500 and 4000 Hz also exhibited high correlations (r > 0.83). In summary, the present study suggests that comparable results were found between tone bursts ABR and AMLR thresholds of 500 and 4000 Hz. A reasonable estimate to the pure tone thresholds in adults with hearing loss is feasible by using tone bursts ABR and AMLR.