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Mycobacterium Abscessus Endocarditis: A Case Report and Literature Review

膿腫分枝桿菌心內膜炎-病例報告與文獻探討

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摘要


膿腫分枝桿菌(Mycobacteriumabscessus)引起的感染性心內膜炎是非常罕見的。大部分膿腫分枝桿菌引起的感染性心內膜炎是發生在瓣膜置換術後之瓣膜。儘管應用了早期手術介入及根據敏感性測驗使用抗生素如amikacin,imipenem,cefoxitin,quinolone,macrolides的治療,此種心內膜炎仍然是亞急性且致命的。我們發表一個29歲的靜脈毒癮者其感染上由膿腫分枝桿菌引起的復發性心內膜。我們報告的病例非常罕見的在其自然瓣膜上受到膿腫分枝桿菌的感染而引起心內膜炎,儘管在抗生素治療後其仍復發。對於血培養陰性的感染性心內膜炎,醫師必須要考慮到膿腫分枝桿菌感染的可能性和其治療上的困難性。

並列摘要


Infective endocarditis owing to Mycobacterium abscessus infection is rarely reported. Most cases of infective endocarditis caused by Mycobacterium abscessus are seen in patients after valve replacement. Although early surgical intervention is recommended and medical treatment with antibiotics according to the susceptibility to the pathogen, such as amikacin, imipenem, cefoxitin, quinolones and macrolides, are applied, the course of such endocarditis is usually subacute and often has fatal outcomes. The present case was a 29-year-old male patient who was an intravenous drug user who had recurrent endocarditis caused by Mycobacterium abscessus. Unusually, our reported case was infected on his native valve. However, we experienced recurrence despite antimicrobial therapy. For culture-negative endocarditis, physicians should consider the possibility of Mycobacterium abscessus infection and related treatment difficulties.

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