Oxcarbazepine-induced Stevens-Johnson Syndrome: A Case Report

Oxcarbazepine誘發史帝文－強森症候群－個案報告

林龍昌(Lung-Chang Lin) ； 賴彬卿(Ping-Chin Lai) ； 楊曉芳(Sheau-Fang Yang) ； 楊瑞成(Rei-Cheng Yang)

《The Kaohsiung Journal of Medical Sciences》 25卷2期 (2009/02) Pp. 82-86

摘要

Carbamazepine是最常見引起史帝文－強森症候群的一種藥物，另一種新的抗癲癇藥物－oxcarbazepine雖然結構上跟carbamazepine類似，卻極少引起史帝文－強森症候群，最近在漢民族的研究顯示carbamazepine引起史帝文－強森症候群是跟人類白血球組織抗原(human leukocyte antigen) HLA-B*1502有強烈的相關性，本篇文章報告一個由oxcarbazepine誘發史帝文－強森症候群的病患，這個病患的人類白血球組織抗原的檢驗結果為HLA-B*1518/B*4001，而HLA-B*1518是HLA-B15的異構體，因此HLA-B*1518在oxcarbazepine誘發史帝文－強森症候群的相關性還須進一步研究。

關鍵字

oxcarbazepine ； 史帝文－強森症候群

並列摘要

Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B*1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied.

並列關鍵字

oxcarbazepine ； Stevens-Johnson syndrome