Huge Sphenoid Sinus Olfactory Neuroblastoma: A Case Report

嗅覺神經母細胞瘤是一種非常罕見源自嗅覺上皮的鼻腔或鼻竇惡性腫瘤，約佔鼻竇惡性腫瘤的5%。最常見的症狀為鼻塞及流鼻血，其次尚有以嗅覺喪失、流鼻水、頭痛等症狀表現。本科經歷一位79歲男性病患，主訴雙側鼻塞已經一年且藥物治療無效，利用鼻腔內視鏡檢查發現後鼻孔被一巨大且黏膜平滑之腫瘤阻塞，且侵犯鼻中隔後方。經鼻竇內視鏡手術將腫瘤完全切除，病理報告證實為嗅覺神經母細胞瘤。嗅覺神經母細胞瘤常發生在篩狀板及上鼻甲，而單純發生在蝶竇十分罕見，目前全球只有四個病例被報導，多以顱內神經異常及頭痛表現。而如此巨大且侵犯雙側蝶竇的病例未曾被報導。

關鍵字

篩狀板；嗅覺神經母細胞瘤；蝶竇

並列摘要

Intranasal or paranasal sinus olfactory neuroblastoma is a rare malignant neoplasm of olfactory neuroepithelial origin, accounting for approximately 5% of paranasal sinus cancers. Most of the presenting symptoms include nasal obstruction, nasal bleeding, anosmia, rhinorrhea, and headache. In this present report, we describe a 79-year-old man who presented with bilateral nasal congestion for more than 1 year. Nasoendoscopy showed a huge, smooth, mucosal tumor in the nasopharynx with extension to the posterior nasal septum. The tumor was completely resected under endonasal endoscopy and the pathology revealed olfactory neuroblastoma. Olfactory neuroblastomas usually arise in the cribriform plate and superior turbinate. However, the origin and isolation of olfactory neuroblastomas to the sphenoid sinus is exceedingly rare. Only four cases of olfactory neuroblastoma isolated in the sphenoid sinus have been described in English literature and the frequency of presenting symptoms with cranial neuropathies and headache. We report a case of primary sphenoid sinus olfactory neuroblastoma with the greatest enlargement reported to date.

並列關鍵字

cribriform plate ； olfactory neuroblastoma ； sphenoid sinus

國際替代計量

Huge Sphenoid Sinus Olfactory Neuroblastoma: A Case Report

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