Correlations of Serum Lipids, Uric Acid, and Albumin Among Mothers, Offspring, and Siblings in Taipei, Taiwan

母子世代血液中四種脂質、尿酸及白蛋白之相關性研究

鄭心嫻(Hsing-Hsien Cheng) ； 楊淑惠(Shwu-Huey Yang) ； 陳成(Cheng Chen) ； 江明樹(Ming-Shu Chiang)

《Acta Paediatrica Taiwanica》 40卷4期 (1999/08) Pp. 225-232

https://doi.org/10.7097/APT.199908.0225

摘要

The purpose of this study was to investigate the correlations of serum lipids, uric acid, and albumin, among mothers (n=111), offspring (n=208), and siblings (n=57) in Taipei, Taiwan. Analytical items included serum triglyceride, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin. Statistical analysis was performed according to the SAS UNIVARIATE procedure; while regression coefficient, parent-offspring regressions, paired-comparison and heritability were estimated. These results show higher heritabilities of four types of serum lipids, uric acid and albumin between mothers and testers (b(subscript YX))or siblings (b(subscript ZX)) by parent-offspring regression analysis. Regression coefficients (b(subscript YX)) of six characters were significantly different (p＜0.05-0.01). Regression coefficients (b(subscript ZX)) for total cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin were significantly different (p＜0.05-0.01), showing the result of genetic control, because their heritabilities were very high at 0.75~1.0, 0.77~1.0, 0.96~1.0, and 0.48~0.82, respectively. This study disclosed that the serum lipids of children in Taipei, Taiwan were significantly correlated with that of parents, which may be attributed to the result of genetic control.

關鍵字

血脂質 ； 母親 ； 幼童 ； 遺傳率 ； 台北

並列摘要

The purpose of this study was to investigate the correlations of serum lipids, uric acid, and albumin, among mothers (n=111), offspring (n=208), and siblings (n=57) in Taipei, Taiwan. Analytical items included serum triglyceride, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin. Statistical analysis was performed according to the SAS UNIVARIATE procedure; while regression coefficient, parent-offspring regressions, paired-comparison and heritability were estimated. These results show higher heritabilities of four types of serum lipids, uric acid and albumin between mothers and testers (b(subscript YX))or siblings (b(subscript ZX)) by parent-offspring regression analysis. Regression coefficients (b(subscript YX)) of six characters were significantly different (p＜0.05-0.01). Regression coefficients (b(subscript ZX)) for total cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin were significantly different (p＜0.05-0.01), showing the result of genetic control, because their heritabilities were very high at 0.75~1.0, 0.77~1.0, 0.96~1.0, and 0.48~0.82, respectively. This study disclosed that the serum lipids of children in Taipei, Taiwan were significantly correlated with that of parents, which may be attributed to the result of genetic control.

並列關鍵字

serum lipids ； mother ； offspring ； heritability ； Taipei