Longitudinal Study of Serum Free Thyroxine and Thyrotropin Levels by Chemiluminescent Immunoassay During Infancy

以化學螢光免疫法測定幼兒血清游離甲狀腺素與甲促素濃度之縱向研究

呂立9Frank L. Lu ； 鄒國英(Kuo-Inn Tsou Yau) ； 蔡克嵩(Ken-Sung Tsai) ； 唐禎瑞(Jen-Ruey Tang) ； 曹伯年(Po-Nien Tsao) ； 蔡文友(Wen-Yu Tsai)

《Acta Paediatrica Taiwanica》 40卷4期 (1999/08) Pp. 255-257

https://doi.org/10.7097/APT.199908.0255

摘要

測定血清游离甲狀素與甲促素濃度是評估甲狀腺功能的重要指標。近年來，化學螢光免疫法成為甲狀腺功能親的高敏感度測驗法。本研究為了了解幼兒時期游离甲狀腺不與甲促素的變化，我們收集90名足月正常幼兒追蹤檢查。檢查時間分別在出生後一週內(n=75)，3個月大(n=66)，6個月大(n=79)，12個月大(n=77)測量其血清游离甲狀腺素與甲促素濃度。結果顯示各年齡層血清中游离甲狀腺素濃度(ng/dL)分別為2.2±0.5,1.3±0.2,1.2±0.2,1.0±0.2，而甲促素濃度(mIU/L)分別為9.7±6.6,3.0±1.6,2.7±1.3,2.5±1.2。本研究提供幼兒時期游离甲狀腺素與甲促素的濃度正常值，并顯示此期間其濃度有隨年齡增加而一目下降之趨勢。

關鍵字

游離甲狀腺素 ； 甲促素 ； 化學螢光免疫法

並列摘要

From October 1996 to December 1997, ninety normal infants born at full-term were enrolled in this study. There were 59 female infants and 31 male infants. Both serum free thyroxine and thyrotropin levels were measured by chemiluminescent immunoassay in the first week (n=75), 3 months (n=66), 6 months (n=79), and 12 months (n=77) of age. Serum free thyroxine levels (ng/dL) (mean ± standard deviation) were 2.2 ± 0.5, 1.3 ± 0.2, 1.2 ± 0.2, 1.0 ± 0.2 for each age group, respectively. Serum thyrotropin levels (mIU/L) (mean ± standard deviation) were 9.7 ± 6.7, 3.0 ± 1.6, 2.7 ± 1.3, 2.5 ± 1.2 for each age group, respectively. There was no significant difference between the levels of these two parameters between male and female. The present study provides the reference data for the normal range of thyroid function during infancy. Our results also show that the serum free T4 and TSH levels tend to decline during the first year of life. From October 1996 to December 1997, ninety normal infants born at full-term were enrolled in this study. There were 59 female infants and 31 male infants. Both serum free thyroxine and thyrotropin levels were measured by chemiluminescent immunoassay in the first week (n=75), 3 months (n=66), 6 months (n=79), and 12 months (n=77) of age. Serum free thyroxine levels (ng/dL) (mean ± standard deviation) were 2.2 ± 0.5, 1.3 ± 0.2, 1.2 ± 0.2, 1.0 ± 0.2 for each age group, respectively. Serum thyrotropin levels (mIU/L) (mean ± standard deviation) were 9.7 ± 6.7, 3.0 ± 1.6, 2.7 ± 1.3, 2.5 ± 1.2 for each age group, respectively. There was no significant difference between the levels of these two parameters between male and female. The present study provides the reference data for the normal range of thyroid function during infancy. Our results also show that the serum free T4 and TSH levels tend to decline during the first year of life.

並列關鍵字

free thyroxine ； thyrotropin ； chemiluminescent immunoassay