Congenital Varicella Syndrome as an Unusual Cause of Congenital Malformation: Report of One Case

先天性水痘症候群爲先天畸形之不尋常症因：一病例報告

黃正昇(Chen-Shen Huang) ； 林炫沛(Shuan-Pei Lin) ； 邱南昌(Nan-Chang Chiu) ； 洪漢陽(Han-Yang Hung)

《Acta Paediatrica Taiwanica》 42卷4期 (2001/08) Pp. 239-242

https://doi.org/10.7097/APT.200108.0239

摘要

懷孕初期母親感染水痘帶狀疱疹病毒造成的胎內感染可導致罕見的先天畸形。我們報告一例先天性水痘症候群的低出生體重兒，臨床發現瘢痕化結痂、雙下肢發育不全、先天性髖關節脫兒、角膜混濁、結腸閉鎖及相當罕見的合併症“泄殖腔異常”。本文目的在提醒小兒科醫師，如果發現新生兒有先天畸形，同時有母親於懷孕早期得到水痘之病史，要想到先天性水痘症候群的可能性。

關鍵字

先天性水痘症候群 ； 水痘帶狀疱疹病毒 ； 先天畸形

並列摘要

Intrauterine infections with varicella-zoster virus following maternal varicella in early pregnancy and resulting in congenital malformations are rare. Herein we report a child with congenital varicella syndrome characterized by low birth weight, cicatricial scarring, hypoplasia of both lower extremities with joint contracture, congenital hip dislocation, corneal opacity, atresia of the sigmoid colon and a rarely associated cloaca anomaly. The varicella IgG remained positive after she was seven months old. Her mother developed chickenpox at the 14th week of gestation. The purpose of this article is to raise pediatricians’ index of suspicion for congenital varicella syndrome when an infant is born with multiple congenital malformations with an apparent history of maternal varicella infection.

並列關鍵字

congenital varicella syndrome ； varicella-zoster virus ； congenital malformation