Use of Cisapride with Magnexium Oxide in Chronic Pediatric Constipation

合併使用平菩賜及氧化鎂以治療小兒慢性便秘

倪衍玄(Yen-Hsuan Ni) ； 林捷忠(Chieh-Chung Lin) ； 張淑華(Shu-Hua Chang) ； 楊俊仁(Chun-Yan Yeung) ； 台灣小兒便秘研究群(Taiwan Pediatric Constipation Study Group)

《Acta Paediatrica Taiwanica》 42卷6期 (2001/12) Pp. 345-349

https://doi.org/10.7097/APT.200112.0345

摘要

小兒慢性功能性便秘是兒科門診常見的總量，但迄無一公認最佳之治療方法。本研究旨在探討合併使用平菩賜及氧化鎂以治療小兒慢性便秘之功效。從1999年十月到2000年三月一共有84位兒童加入本研究。男：女爲51：33，年齡在1至7歲之間。這些人每週排便次數小於兩次，且此等便秘情況至少已存在一個月以上。他們隨機分爲氧化鎂治療組或平菩賜加氧化鎂治療組，予以治療四週，其間每週均記錄其排便狀況。經過一週治療之後，得到良好之效果，即每週排便次數大於三次的病童，在平菩賜加氧化鎂治療組有68.2%，而氧化鎂治療組有57.5%(p=ns)。經過四週治療之後，得到良好之效果，即每週排便次數大於三次的病童，在平菩賜加氧化鎂治療組有90.9%，而氧化鎂治療組有67.5%(p=0.013)。兩組病童在藥物副作用上並無不同。結論是平菩賜加氧化鎂對小兒慢性便秘之治療可增加排便次數。

關鍵字

平菩賜 ； 氧化鎂 ； 小兒慢性便秘

並列摘要

Functional constipation in children is a common problem in daily practice, however there is currently no accepted optimal treatment of choice. This study investigated the effect of cisapride in the treatment of pediatric constipation when combined with magnesium oxide (MgO). This prospective study enrolled children with chronic constipation. They were randomly assigned to either MgO (125 mg three times a day for patients weighing less than 20kg or 250 mg three times a day for those weighing more than 20kg), or cisapride 0.2mg/kg (max 5mg/dose) plus MgO for 4 weeks. Twenty-one doctors in 19 major medical centers or hospitals in Taiwan with well- established pediatric departments participated in this study from October 1999 to March 2000. 84 children (51 males, 33 females, 1-7 years of age) with fewer than 2 spontaneous bowel movements per week for at least one month completed the study. After 1 week of therapy, a good response, defined as 3 or more bowel movements per week, was achieved in 30 (68.2%) of children treated with cisapride and MgO compared with 23 (57.5%) children treated with MgO alone (p=n.s.). At the end of the 4-week treatment period, 90.9% of the children in cisapride group compared with 67.5% of the children in MgO group achieved a good response (p=0.013). There was no statistical difference between the two groups in terms of the side effects and stool characteristics. In conclusion, it appears that cisapride in combination with MgO may have a synergistic effect and improves the frequency of stool passage in pediatric functional constipation.

並列關鍵字

cisapride ； magnesium oxide ； constipation ； children