- 期刊
Evaluation of the Serum Antioxidant Status in Asthmatic Children
氣喘兒童血清中抗氧化狀態之研究
摘要
活性氧爲氧的衍生物是氧被部份還原的結果，當活性氧大量産生而將抗氧化物消耗胎盡或抗氧化系統産生缺失而無法發揮作用時，便會使細胞內氧化還原的恆定狀態發生改變，造成氧化性傷害。許多研究報告指出此種狀態與許多疾病的致病機轉有關，如老化，動脈硬化，糖尿病，過敏性疾病甚至癌症。在這個研究中我們發現在國小一年級的氣喘學童中，其血中抗氧化狀態比起正常學童呈現有統計學意義的下降。磆氣喘學童其紅血球內抗氧化劑SOD（超氧岐化鋂）呈現大幅地上昇，SOD（超氧岐化鋂）可加速O2•dismutation成H2O2（過氧化氫）保護細胞不受超級氧的攻擊。但另一種抗氧化劑GPx（麩胱甘太過氧化鋂），其利用GSH（還原態之麩胱甘太）作爲受質，能將H2O2代謝爲水之外，還能將lipidhydroperoxide（脂質氫過氧化物）代謝成無毒的alcohols（乙醇），其在氣喘學童上是下降的。此發現顯示氣喘學童的確承受了較大的氧化性壓力。
並列摘要
Many studies have shown the balance between the oxygen reactive species (ROS) and the antioxidant capacities, and that the massive ROS generation could lead to cell damage and diseases such as atherosclerosis, aging and cancer. Changes in antioxidant capacity like free radicals scavenging antioxidant agents such as vitamin F, C content, serum concentrations of bilirubin, uric acid, albumin and antioxidant enzyme systems like SOD, and GPx activities have been described to be related to many diseases. However, the research on chronic airway inflammatory disease and the antioxidant defence system is still not enough. Understanding of the antioxidant status and antioxidant enzymes in asthmatic patients is still unclear. In the present controlled study, we investigated the total antioxidant status (TAS) in serum and the antioxidant enzyme (total SOD and GPx) activities in 46 asthmatic children and 52 normal controls. The serum level of TAS in asthmatic children was significantly lower than the controls. The SOD concentration in asthmatic children was higher than the control, however the GPx was much lower than the control children, even though it was not statistical significance. In conclusion, these results suggested the existence of higher oxidative stress and reactive oxygen species (ROS) in asthmatic children, and that the antioxidant capacities in asthmatic children were altered. If the production of ROS was persistent, it would result in chronic inflammation and the imbalance of oxidative-reductive status in those patients.
延伸閱讀
- 周莉菁（2011）。台灣中部某國小學童視力相關抗氧化素攝取狀況調查〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2011.00159
- Wu, J. Y., Shyur, S. D., Huang, L. H., Weng, J. D., Chuo, H. T., Ma, Y. C., Lin, S. C., & Wu, W. C. (2003). 氣喘病童症狀積分，肺功能及過敏原特異性IgE抗體之評估. 中華民國兒童胸腔醫學會雜誌, 4(1), 1-7. https://doi.org/10.6322/JPRD.200308_4(1).0001
- Lin, W. C. (2020). 以吐氣代謝體學偵測氣喘學童之呼吸危害研究 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU202003411
- 陳淑如、陳五常、邱泓文、鄭綺（2006）。氣喘兒童休息及活動狀態下的心率變異度。台灣醫學，10(1)，20-27。https://doi.org/10.6320/FJM.2006.10(1).03
- 戴任恭、吳俊仁、譚棉心（2004）。進展中的兒童肺高血壓藥物治療。Acta Paediatrica Taiwanica，45(s)，1-5。https://doi.org/10.7097/APT.200411.0001