Portable Laser Doppler Flowmetry in Studying the Effect of Diabetes Mellitus on Cutaneous Microcirculation

掌上型雷射都卜勒微循環血流儀與臨床應用

謝志輝(Chih-Hui Hsieh) ； 楊永健(Eng-Kean Yeong) ； 林康平(Kang-Ping Lin)

《Journal of Medical and Biological Engineering》 23卷1期 (2003/03) Pp. 13-18

摘要

雷射都卜勒量測技術是已知微循環血流量測法中最靈敏最方便之方法，本文提出一微小化設計之掌上型微循環儀設計與開發，此系統包含一微小化之光纖探頭，與一功能強大之數位訊號處理器為核心的訊號擷取硬體，能達到即時擷取分析之目的。硬體之驗證除了以麥克遜干涉儀為架構之光學測試系統來驗證外，並且以臨床上之測試來驗證功能，藉此提昇微循環儀相關應用範圍，本文提出應用相對血流能力變化參數為判別法則之微循環儀，能成功判別糖尿病患下肢潰爛之先兆，提早預防治療。

關鍵字

雷射都卜勒 ； 微循環血流 ； 相對血流能力 ； 數位訊號處理器

並列摘要

Microcirculatory blood flow can be measured using laser Doppler flowmetry (LDF). However, the size and weight of the currently used system can be improved to make it light and portable. This paper describes a portable laser Doppler flowmetry (pLDF) system for taking real-time blood flow measurements in the dorsal foot of a diabetic. The system is comprised of a miniaturized probe, a fast digital signal processing (DSP) unit. The probe comprises an IR laser diode to illuminate tissue through an optical fiber and a photodetector, positioned 1 mm from the laser spot. The DSP uses the FFT based algorithm to estimate the laser Doppler power spectrum density. The pLDF unit is applied to the clinical evaluation of diabetes mellitus and a very high correlation was observed to exist between relative flow capacity (RFC) and occurrence of ulcer.

並列關鍵字

Laser Doppler ； Microcirculation ； RFC ； DSP