Degradation Behavior of Porous Calcium Phosphates

理想的骨架除了考量材料本身的化性與結構外，需要評估其孔隙率、孔洞大小及機械性質等因素以研究降解性行為。本實驗添加孔原形成劑(PVA)，以燒結法製作多孔鈣磷骨架，將此種材料浸泡於Hanks模擬體液中，研究其機械強度變化及重量損失，並觀察微結構形態。結果發現陶瓷骨架表面形成數百微米巨孔與許多微孔的結構，經浸泡於模擬體液後，出現浸蝕引起的微孔。各燒結體抗壓強度隨PVA添加量增加而降低，隨浸泡時間增加各陶瓷骨架之抗壓強度降低，且重量損失增加。本研究的多孔材料或許可使用在骨缺損修補。

關鍵字

組織工程；多孔骨架；機械性質；鈣磷酸鹽

並列摘要

Concerning an ideal scaffold, evaluation of many factors, such as porosity, porous size and mechanical properties are needed so as to investigate degradation behavior in addition to chemistry and structure of materials used. In this study, the porous calcium phosphates were made on addition of a pore-former compound (PVA) by sinter processing. Mechanical properties, morphology, and weight change in in vitro testing were assessed. Experimental results indicated macropore sizes as large as hundreds of micrometers were generated and many micropores were also observed in the sintered body. After immersion in Hanks' solution, on the body surface there was a pitting appearance with immersion-induced micropores. The compressive strength of as-sintered bodies decreased steadily with addition of PVA. With increasing immersion time, the compressive strength and modulus of various porous bodies decreased and the weight loss increased. The biomedical uses of the present porous materials might limit to use as bone defect repair.

並列關鍵字

Tissue engineering ； Porous scaffold ； Mechanical property ； Calcium phosphate

國際替代計量

Degradation Behavior of Porous Calcium Phosphates

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