- 期刊
Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography
應用11C-acetate正子電腦斷層定量分析於鼻咽癌之診斷
摘要
對11C-acetate正子電腦斷層影像定量分析來說，目前發展的幾個動態模型都是基於心臟造影提出。本研究旨在應用其中一個動態模型於腫瘤診斷，評估其可行性，並探討估算所得到的參數意義及臨床價值。十名病人，其中包含五名鼻咽癌病人及五名控制組病人，每位病人皆於鼻咽及肌肉各圈選一個ROI，並以非線性最小平方法估測動態模型中的四個參數，最後以這些參數計算11C-acetate攝取比例K值。我們發現在兩組病人間，鼻咽之K值有相當明顯的差異：在鼻咽癌病人平均為0.2675±0.1562，而控制組病人為0.0763±0.0425。此外，鼻咽癌病人的11C-acetate流入速率常數也高於控制組病人，但清除速率常數卻較低。在肌肉部分，兩組病人的速率常數並無明顯差異。這些結果顯示，使用定量分析可得到具生理意義的參數估測，而腫瘤的參數差異可用於腫瘤診斷，並可供臨床醫師作為客觀且定量的診斷依據。
並列摘要
Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.
延伸閱讀
- 許維中、丁禮莉、鍾娜娜、洪瑞隆、柯政郁、王博民、詹淑卿（2012）。比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響。放射治療與腫瘤學，19(3)，181-188。https://doi.org/10.6316/TRO/201219(3)181
- Chan, S. C., Hsu, C. L., Lin, C. Y., & Ng, S. H. (2016). 於鼻咽癌盛行區，葡萄糖正子暨電腦斷層掃描檢查做為局部侵犯晚期病人治療後的例行追蹤工具之探討. 核子醫學暨分子影像雜誌, 29(1), 10-22. https://doi.org/10.6332/ANMMI.2901.002
- 詹勝男（2010）。鼻咽癌病理切片輔助診斷之初期研究〔碩士論文，朝陽科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0078-0601201112112428
- 王永成、黃國茂、鄭慶明、陳威璋（1993）。電腦斷層攝影對慢性鼻竇炎的評估及在內視鏡手術上之應用。中華放射線醫學雜誌，18(3)，279-285。https://www.airitilibrary.com/Article/Detail?DocID=10188940-199309-18-3-279-285-a
- 丁禮莉、雷德、王博民、方麗麗、鍾娜娜（1996）。鼻咽癌病人放射線黏膜炎之抑制－比較Salcoat與Dexaltin之隨機取樣試驗。放射治療與腫瘤學，3(2)，101-104。https://doi.org/10.6316/TRO/199603(2)101