Primary Tumor Volume and Treatment Outcome in T3-staged Nasopharyngeal Carcinoma

腫瘤分期T3鼻咽癌之原發腫瘤體積對治療結果之影響

張正權(Cheng-Chuan Chang) ； 陳穆寬(Mu-Kuan Chen) ； 劉幕台(Mu-Tai Liu) ； 胡華堃(Hwa-Koon Wu)

《The Changhua Journal of Medicine》 8卷1期 (2003/01) Pp. 7-12

摘要

背景及目的：在以放射線治療為主的癌症當中，原發腫瘤體積已被視為是重要的預後因素，尤其在腫瘤分期T3頭頸癌，腫瘤體積的變異性相當大。在鼻咽癌，這方面的研究卻付之闕如，因此，本研究的目的在探討腫瘤分期T3鼻咽癌的原發腫瘤體積對治療結果的影響。
方法：以高解析度電腦斷層使用區域合成法(summation of area technique)精算40位腫瘤分期T3鼻咽癌之原發腫瘤體積，並與治療之存活曲線做統計分析。
結果：原發腫瘤體積大於30毫升的預後明顯較差，且達統計顯著性(P=0.0001)。Cox迴歸分析顯示原發腫瘤體積是唯一的預後因子(P=0.011)。
結論：同樣腫瘤分期T3的鼻咽癌病人，原以腫瘤體積較大者預後較差，因此，應給予更積極的治療方法。

關鍵字

鼻咽癌 ； 腫瘤分期T3 ； 原發腫瘤體積

並列摘要

Background and purpose: Tumor volume is an important prognostic factor in patients with malignancy who are treated with primary radiotherapy. A substantial variability in the T3-staged head and neck cancers has been observed. We assessed the relationship between primary tumor volume and treatment outcome in T3-staged nasopharyngeal carcinoma.
Methods: Forty newly diagnosed T3-staged patients who were treated with high dose radiation therapy participated in the study. Computed tomography-derived primary tumor volume was obtained from the summation of area technique. Results: The median primary tumor volume was 29.6mL (range, 8.0-131.8mL). After segregating the primary tumor volume into 2 subgroups (≤30mL, ＞30mL), large primary tumor volume was associated with a significantly poorer disease-specific survival (P=0.0001). The Cox proportional hazards regression model revealed that only primary tumor volume was statistically significant (P=0.011).
Conclusion: In T3-staged nasopharyngeal carcinoma, a substantial variation of primary tumor volume was observed. Volumetric measurements of primary tumors in T3-staged nasopharyngeal carcinoma could better refine our treatment strategy.

並列關鍵字

nasopharyngeal carcinoma ； T3-staged ； primary tumor volume