Waldeyer's ring is the primary site of non-Hodgkin's lymphoma (NHL) involvement in approximately 5% to 10% of all lymphoma patients. Of all Waldeyer's ring NHLs, the tonsil is the most frequent site, followed by the nasopharynx. Lymphomas arising from base of the tongue are less frequent, accounting for 7% of all primary Waldeyer's ring NHLs. We report a case of NHL involving a tongue base tumor in a 63-year-old man who complained of a foreign body sensation when swallowing. Clinical examination showed a firm, nontender, 2.5×2.0×1.5cm mass on the left tongue base. Direct laryngoscopy and biopsy were performed. Pathological examination showed the presence of diffuse large cell, with B cell lineage. The patient was treated with CHOP regimen, and no evidence of recurrence has been noted during follow-up.