Conserving Surgical Treatment Plus Radiotherapy for Breast Cancer

Background and purpose: Breast conserving surgery (BCS) followed by local radiotherapy has been used in early-stage breast cancer for years. This study is to assess the survival and local control at different stages. Methods: Forty-three patients treated with conservative surgery and radiotherapy at Changhua Christian Hospital were reviewed from 1995 to 1998. The survival and local control rates were calculated using the Kaplan-Meier method along with the log-rank test for the difference of each group. Cox regression was used for multivariate analysis of the significance of different factors which may influence survival rates of both groups. Results: The overall survival of the patient population was 90.7 % at 5 years. The five-year survival rate of stage I, II, and III were 100%, 88.2% and 50%, respectively. There was significant difference of survival rate between different stages when using the single variable log-rank test (P = 0.036). The significant factors that influence survival rate were stage and the status of local control in multivariate analysis. The five-year local control rate for T1 disease was 100%. However, it was 89.3% for T2 disease. Factors of chemotherapy, delayed radiotherapy, radiotherapy to internal mammary nodes, radiotherapy to axillary nodes and stages had no significantly influence local control noted in the analysis. Conclusion: Breast-conserving surgery plus radiotherapy provides the equal treatment outcome to radical mastectomy in early-stage breast cancer. The earlier the stage along with better local treatment demonstrated an increase in survival rate.

並列關鍵字

breast cancer ； breast conservative therapy ； survival rate ； local control rate

國際替代計量

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