- 期刊
Protective Effects of L-glutamine and Its Related Analogs on Mouse Endotoxin Shock
並列摘要
Background and purpose: L-glutamine (Gin) has been demonstrated to be effective in endotoxin-induced mortality. However, to our knowledge, the efficacy of its related analogs-L-asparagine (Asn), L-glutamate (Glu), L-aspartate (Asp), and L-lysine (Lys, as an unrelated control) in protecting against endotoxin-induced shock has not been investigated. Methods: Twenty BALB/c mice received a minimal lethal dose of Escherichia coli lipopolysaccharide (LPS) with a simultaneous intraperitoneal injection of Gln, Glu, Asn, Asp, or Lys at various doses and times. The animals were observed for 72 h to determine their survival rates. Dose-response and time-course studies were performed to compare the relative efficacies of the amino acids. Results: The survival rate for the control group was low (20%). Asn and Gln were effective in protecting animals against LPS-induced shock, with the survival rates of 90% and 85%, respectively. Glu and Asp were moderately effective, and Lys was ineffective. The estimated optimal doses for protection were 1 and 10 mg per mouse for Gln and Asn, respectively. The protective effect of these amino acids was nullified when they were injected 3 h after LPS injection. Conclusion: Among the tested structural analogs of Gln, Asn was the most effective in protecting endotoxin-induced shock in mice. Glu and Asp were less effective than Gln, and Lys was totally ineffective.
並列關鍵字
L-glutamine ； L-asparagine ； L-glutamate ； L-aspartate ； L-lysine ； endotoxin shock ； mouse ； lipopolysaccharide ； protection延伸閱讀
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