Predictors of Survival among Young Adult Patients with Early Recurrence of Hepatocellular Carcinoma after Hepatectomy

Chih-Jan Ko ； Kuo-Hua Lin ； Ping-Yi Lin ； Tung-Yi Ko ； Yao-Li Chen ； Shou-Jen Kuo

《The Changhua Journal of Medicine》 12卷1期 (2014/03) Pp. 1-8

並列摘要

Background: Studies have shown that young adults with hepatocellular carcinoma (HCC), especially those≤40 years, are at high risk of recurrence after hepatectomy even though most of them have adequate residual liver function. The aim of this study was to analyze the risk factors associated with early recurrence of HCC in young adults after hepatectomy. Methods: We enrolled 45 patients with resectable HCC who underwent hepatectomy at a single medical center during the period March 1997 to November 2010. All patients were ≤ 40 years at the time of diagnosis. Prognostic factors of overall survival were examined using a proportional hazard regression model. The independent t test and the Pearson chi-squared test were used to examine differences in demographic and clinical characteristics between patients with HCC recurrence one year after surgery and those without recurrence. The prognostic factors were studied using the Kaplan-Meier method with the log-rank test to detect differences in cumulative survival rates of young adult patients with HCC. Results: During the follow-up period, the rate of post-resection HCC recurrence was 53.5% (24 of 45). Univariate analysis revealed that tumor size＞5.0 cm, the presence of HCV infection, recurrence of HCC within 12 months after surgery, and specimen margin＜1 cm were predictors of poor survival after hepatectomy. Univariate analysis revealed that tumor size, serum alpha fetoprotein, the type of operation, and tumor stage were significant predictors of recurrence one year after hepatectomy. Conclusion: Large tumor size is predictive of early tumor recurrence and poor survival after salvage interventions in young adults.

並列關鍵字

Hepatocellular carcinoma ； Young adult patients ； Early recurrence ； Hepatectomy ； Tumor size