5-Fluorouracil (5-FU)-Induced Sinus Bradycardia: A Case Report

5-fluorouracil (5-FU) is the backbone of the majority of approved chemotherapy regimens for colorectal cancer. Common adverse events of 5-FU include diarrhea, nausea, mucositis, and bone marrow suppression. Cardiotoxicity is not common. Sinus bradycardia induced by 5-FU is a rare complication but can be fatal if not managed well. We present a 79-year-old woman with colon cancer who developed bradycardia while receiving 5-FU infusion. The arrhythmia returned to sinus rhythm after cessation of 5-FU infusion. The mechanism of 5-FU-induced cardiotoxicity is unclear and there are no prophylactic medications that can prevent this side effect. If symptoms and signs of cardiovascular anomalies develop, infusion should be stopped immediately and a work-up performed. Rechallenging with a lower dose of 5-FU, shifting to an oral prodrug of 5-FU, or replacing 5-FU with raltitrexed should be considered based on risk-benefit assessment.

並列關鍵字

5-fluorouracil ； cardiotoxicity ； bradycardia

被引用紀錄

邱俊旺 (2013). 相對重要性及區域社群偵測在引用網路結構上之應用 [master's thesis, National Tsing Hua University]. Airiti Library. https://doi.org/10.6843/NTHU.2013.00736

何聰儒（2009）。利用群集分析與線性迴歸推估高速公路旅行時間之研究〔碩士論文，國立交通大學〕。華藝線上圖書館。https://doi.org/10.6842/NCTU.2009.00581

Wu, N. T. (2017). 結合微流道之銦鎵鋅氧化物薄膜電晶體應用於蛋白質與生物素混合反應之檢測 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU201702330

Chang, H. T. (2015). 攝影影像之重新構圖與影像調整 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2015.02776

Chang, H. Y. (2015). 基於三維快閃記憶體之軟體控制部分區塊抹除設計 [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2015.00932

國際替代計量

5-Fluorouracil (5-FU)-Induced Sinus Bradycardia: A Case Report

全文下載

主題瀏覽