單一劑量Sofradex耳滴劑滴入對預防中耳通氣管置入手術術後早期耳漏之成效

Prophylaxis of Early Posttympanostomy Otorrhea: Effectiveness of a single Dose of Sofradex Otic Drops

林鴻任(Hung-Jen Lin) ； 蘇茂昌(Mao-Chang Su) ； 辛宗翰(Chung-Han Hsin) ； 李孟智(Meng-Chih Lee) ； 歐哲甫(Che-Fu Ou)

《中山醫學雜誌》 14卷2期 (2003/05) Pp. 279-285

https://doi.org/10.30096/CSMJ.200305.0009

摘要

BACKGROUND: Myringotomy and ventilation tube insertion are commonly used to treat persistent otitis media with effusion and recurrent otitis media. Incidence of early otorrhea within two weeks after surgery has been reported as high as 30 percent and is the most frequent post-surgical complication. It is important to find effective prophylactic treatment.
METHOD: From October 1998 to September 2001,110 otherwise healthy children (61 males and 49 males) who presented with bilateral chronic otitis media with effusion (persistent effusion more than 3 months) or recurrent acute otitis media (more than 4-6 episodes of acute otitis media per year) and who subsequently were treated with myringotomy and ventilation tube insertion at this clinic were recruited for study. Age range was 1 to 10 years, and mean age was 5 years. Subjects had undergone no other concurrent procedures. Patients who had previously been treated with myringotomy and/or tube insertion were excluded. Procedures were performed by a senior surgeon after aseptic ear canal preparation, and the same type of ventilation tube was used. The right ear was treated with three drops of Sofradex, and the left ear served as the control. Subjects were followed for two weeks.
RESULTS: Early posttympanostomy otorrhea developed in nine ears treated with Sofradex and in twelve control ears. There was no significant difference between ears in the same individual (p-value = 0.88).
CONCLUSION: Instillation of a single Sofradex dose did not significantly prevent early posttympanostomy otorrhea.

關鍵字

單一劑量 ； Sofradex ； 中耳通氣管 ； 早期耳漏

並列摘要

BACKGROUND: Myringotomy and ventilation tube insertion are commonly used to treat persistent otitis media with effusion and recurrent otitis media. Incidence of early otorrhea within two weeks after surgery has been reported as high as 30 percent and is the most frequent post-surgical complication. It is important to find effective prophylactic treatment.
METHOD: From October 1998 to September 2001,110 otherwise healthy children (61 males and 49 males) who presented with bilateral chronic otitis media with effusion (persistent effusion more than 3 months) or recurrent acute otitis media (more than 4-6 episodes of acute otitis media per year) and who subsequently were treated with myringotomy and ventilation tube insertion at this clinic were recruited for study. Age range was 1 to 10 years, and mean age was 5 years. Subjects had undergone no other concurrent procedures. Patients who had previously been treated with myringotomy and/or tube insertion were excluded. Procedures were performed by a senior surgeon after aseptic ear canal preparation, and the same type of ventilation tube was used. The right ear was treated with three drops of Sofradex, and the left ear served as the control. Subjects were followed for two weeks.
RESULTS: Early posttympanostomy otorrhea developed in nine ears treated with Sofradex and in twelve control ears. There was no significant difference between ears in the same individual (p-value = 0.88).
CONCLUSION: Instillation of a single Sofradex dose did not significantly prevent early posttympanostomy otorrhea.

並列關鍵字

single dose ； Sofradex ； ventilation tube ； early posttympanostomy otorrhea