This article will carry out a research on Zhou Fenling's prose on terms that are familiar in medical science like insomnia, sjogrens syndrome, ucide and drug dependence in semiotics approaches to find out the reconstruction of semiotics significance by creating meaning of unique political science and philosophy on the patients bodies. These literary works had renewed and deepened our knowledge on diseases. Disease/writing has become an important and inevitable signs to separate the writer and others due to its nature of mimicking or creating inevitable modes like absurdity, estrangement, nothingness, anxiety and death in life. This article will make a profound research on how the author subverts the literary convention of the coding process of prose, granting a particular sense of beauty to the prose of disease writing, and creating an aesthetic value on disease.